Rotavirus particles with chimeric surface proteins
US10192025B2 · kind B2 · utility
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14Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 8, 2014 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Jul 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2720/12351
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunizing a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.