Patent · US Active

Local delivery forms of acriflavine for treating tumors

US10195190B2 · kind B2 · utility

0Cited by

9References

5Claims

0Family size

Assignee

THE JOHNS HOPKINS UNIVERSITY · US

Inventors

Henry Brem · Baltimore, US
Antonella Mangraviti · Baltimore, US
Alessandro Olivi · Baltimore, US
Betty M. Tyler · Baltimore, US
Tula Raghavan · Baltimore, US

Key dates

Filing date	Feb 11, 2016
Grant date	Feb 5, 2019
Priority date	—
Expiry date	Feb 11, 2036

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Local delivery formulations of the antineoplastic and microbicide agent acriflavine, and methods of making and using thereof are significantly more efficacious at increasing the median survival of subjects with proliferative disease than systemic administrations of acriflavine. The local delivery formulations of acriflavine show a dose-dependent increase in the median survival of subjects. The local delivery forms provide the increased efficacy without the toxicity associated with systemic administration of the agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.