Preparation of therapeutic exosomes using membrane proteins
US10195290B1 · kind B1 · utility
11Cited by
1References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2018 |
| Grant date | Feb 5, 2019 |
| Priority date | — |
| Expiry date | Aug 24, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.