Tissue engineering device and construction of vascularized dermis
US10195644B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 13, 2013 |
| Grant date | Feb 5, 2019 |
| Priority date | — |
| Expiry date | Apr 5, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2240/001
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location. This technology can also be used for the microvasculature fabrication using appropriate human microvascular endothelial cells and fibrin to form the microvasculature. When printing human microvascular endothelial cells in conjunction with the fibrin, the cells aligned themselves inside the channels and proliferated to form confluent linings. The 3D tubular structure was also found in the printed patterns. Simultaneously printing biological materials to form a three-dimensional cellular scaffold promotes human microvascular endothelial cell proliferation and microvasculature formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.