Substituted acethydrazide derivative, preparation method and use thereof

US10196346B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Junhai Xiao · Beijing, CN
• Lili Wang · Beijing, CN
• Long Long · Beijing, CN
• Wei Li · Lexington, US
• Haoming LUO · Beijing, CN
• Feifei Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Yunde Xie · Beijing, CN
• Xingzhou Li · Beijing, CN
• Xinbo Zhou · Beijing, CN
• Xiaokui Wang · Beijing, CN
• Ruiyuan CAO · Beijing, CN

Key dates

• Filing date: Nov 20, 2017
• Grant date: Feb 5, 2019
• Expiry date: Nov 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.