Patent · US Active

2-alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof

US10196359B2 · kind B2 · utility

0Cited by

0References

5Claims

0Family size

Assignee

FUDAN UNIVERSITY · CN

Inventors

Deyong YE · Shanghai, CN
Yali Li · Cambridge, GB
Lu Zhou · Santa Clara, US
Penghui WANG · Beijing, CN
Yong Chu · Rockville, US
Haojun Gong · Shanghai, CN
Qi Huang · Moorpark, US
Yan Chen · Taichung, TW
Zhikuan Zhang · Tangxia, CN

Key dates

Filing date	Jul 24, 2015
Grant date	Feb 5, 2019
Priority date	—
Expiry date	Jul 24, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D239/42
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

2-alkoxy benzene formyl arylamine compounds and their pharmaceutical salts are disclosed. The compounds can act as sphingomyelin synthase (SMS) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin (SM). The pharmaceutically acceptable salts and pharmaceutical compositions of the compounds are used as active ingredients in drugs which can prevent and cure diseases caused by SM level abnormal increase. These diseases include atherosclerosis, fatty liver, obesity, type diabetes, and other metabolic syndromes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.