Pyrimidine carboxamides as sodium channel blockers

US10196364B2 · kind B2 · utility

Assignee

• PURDUE PHARMA L.P. · US

Inventors

• Jeffrey Lockman · Princeton Junction, US
• Chiyou Ni · Montgomery, US
• Jae Hyun Park · Yongin-si, KR
• Minnie Park · Princeton Junction, US
• Bin Shao · Shanghai, CN
• Laykea Tafesse · Robinsville, US
• Jiangchao Yao · Princeton, US
• Mark A. Youngman · Warminster, US

Key dates

• Filing date: Apr 6, 2017
• Grant date: Feb 5, 2019
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.