Hydrochloride salts of 8-[1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxymethyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one and preparation process therefor

US10196394B2 · kind B2 · utility

Assignee

• OPKO Health, Inc. · US

Inventors

• Mengwei Hu · Hackettstown, US
• Sunil Paliwal · Manalapan, US
• Neng-Yang Shih · Lexington, US
• Frank Bruno Guenter · Thalwil, CH
• Ingrid Mergelsberg · Mahwah, US

Key dates

• Filing date: Apr 10, 2015
• Grant date: Feb 5, 2019
• Expiry date: Apr 10, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.