Baicalin magnesium compound and its preparation method and application

US10196417B2 · kind B2 · utility

Assignee

• CHENGDE MEDCIAL UNIVERSITY · CN

Inventors

• Cuizhe Liu · Laishui, CN
• Zhixuan Wang · Irvine, US
• Ceyu Miao · Laishui, CN
• Liyan Liu · Beijing, CN
• Hefei Xue · Laishui, CN
• Xigang LIU · 红钢城街道, CN
• Wenshan Du · Laishui, CN
• Yixin Liu · Fujian, CN
• Lin Zhang · Beijing, CN
• Xiaoxia Mao · Laishui, CN
• Jinjun Liu · Tuji, CN
• Guiqin Zhao · Laishui, CN

Key dates

• Filing date: Aug 1, 2018
• Grant date: Feb 5, 2019
• Expiry date: Aug 1, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H1/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A baicalin magnesium compound and methods for preparing and extracting the same. The method for preparing the baicalin magnesium compound includes steps of preparation of a baicalin suspension, preparation of a magnesium ion-containing suspension, reaction and drying. The method for extracting the baicalin magnesium compound includes steps of pretreatment of macroporous resin, extraction, adsorption and elution, concentration and drying and purification. The methods restores the baicalin to the original form as found in radix scutellariae, and the baicalin magnesium compound may be used as a substitute for the baicalin in pharmaceutical applications. As compared to the baicalin, the baicalin magnesium has a greatly increased solubility, faster adsorption rate and higher oral bioavailability. The baicalin magnesium compound may also be easily formulated as a water-soluble injection or a powder injection. Pharmacological tests show that the baicalin magnesium compound is more pharmacologically active than the baicalin.