NPR-B agonists

US10196423B2 · kind B2 · utility

Assignee

• Shire Orphan Therapies GmbH · DE

Inventors

• Frank Osterkamp · Berlin, DE
• Heiko Hawlisch · Berlin, DE
• Gerd Hummel · Berlin, DE
• Tobias Knaute · Berlin, DE
• Ulf Reimer · Berlin, DE
• Ulrich Reineke · Berlin, DE
• Bernadett Simon · Bonn, DE
• Uwe Richter · Berlin, DE
• Edgar Specker · Berlin, DE
• Markus Woischnik · Berlin, DE
• Mark R. Helberg · Arlington, US

Key dates

• Filing date: May 9, 2018
• Grant date: Feb 5, 2019
• Expiry date: May 9, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds.