Methods of inhibiting growth of a colon cancer tumor in a subject by administering monoclonal antibodies to G protein-coupled receptor 49 (GPR49)

US10196442B2 · kind B2 · utility

Assignee

• Bionomics Limited · AU

Inventors

• Christopher L. Reyes · Adelaide, AU
• Peter Chu · Hawthorne, US
• Xiangyang Tan · Tewksbury, US
• Christilyn Graff · Cambridge, US
• Weixing Yang · Newton, US

Key dates

• Filing date: Dec 11, 2015
• Grant date: Feb 5, 2019
• Expiry date: Dec 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies, and methods of treating cancer with such antibodies.