Binding molecules to the human OX40 receptor

US10196452B2 · kind B2 · utility

Assignees

• PFIZER INC. · US
• Bristol-Myers Squibb Company · US

Inventors

• Jing Min · Chesterfield, US
• Yanli Wu · Ballwin, US
• Rory F. Finn · Ballwin, US
• Barrett R. Thiele · Chesterfield, US
• Wei Liao · Chesterfield, US
• Ronald P. Gladue · Stonington, US
• Arvind Rajpal · San Francisco, US
• Timothy J. Paradis · Richmond, US
• Peter Brams · Sacramento, US
• Brigitte Devaux · Palo Alto, US
• Yi Wu · Milpitas, US
• Kristopher Toy · San Jose, US
• Heidi N. LeBlanc · Mountain View, US
• Haichun Huang · Fremont, US

Key dates

• Filing date: Nov 8, 2017
• Grant date: Feb 5, 2019
• Expiry date: Nov 8, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.