Engineered lumenized vascular networks and support matrix

US10196596B2 · kind B2 · utility

Assignee

• National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR) · US

Inventors

• James A. Glazier · Bloomington, US
• Abdelkrim Alileche · Boise, US
• Abbas Shirinifard · Bloomington, US
• Dragos Amarie · Bloomington, US

Key dates

• Filing date: Feb 22, 2016
• Grant date: Feb 5, 2019
• Expiry date: Jul 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.