Reconstituted nipple skin model
US10196607B2 · kind B2 · utility
0Cited by
4References
21Claims
0Family size
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Key dates
| Filing date | Jan 12, 2015 |
| Grant date | Feb 5, 2019 |
| Priority date | — |
| Expiry date | Feb 18, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/904
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.