System and method for detection of nucleic acids

US10196678B2 · kind B2 · utility

Assignees

• ALVEO Technologies, Inc. · US
• The Regents of the University of California · US

Inventors

• Sumita Pennathur · Goleta, US
• Peter Crisalli · Mountain View, US
• Ronald Phillip Chiarello · Los Gatos, US

Key dates

• Filing date: Nov 7, 2014
• Grant date: Feb 5, 2019
• Expiry date: Oct 6, 2035

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L3/5027
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Embodiments provide detection systems and methods for detecting the presence of a nucleic acid in one or more samples. In a detection method, a sample and one or more nucleic acid probes are introduced into a channel. A first potential difference is applied across the length of the channel in a first direction, and a first electrical property value is detected. Subsequently, a second potential difference is applied across the length of the channel in a second opposite direction, and a second electrical property value is detected. Presence or absence of a nucleic acid in the channel is determined based on a comparison between the first and second electrical property values.