Patent · US Active

Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays

US10197559B2 · kind B2 · utility

0Cited by

0References

6Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Hartmut Duefel · Schlehdorf, DE
Alexander Riedel · Munich, DE
Peter Schaarschmidt · Ulm, DE
Urban Schmitt · Oberhausen, DE
Christian Scholz · Penzberg, DE

Key dates

Filing date	Mar 6, 2015
Grant date	Feb 5, 2019
Priority date	—
Expiry date	Apr 27, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/735
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention concerns a fusion polypeptide including several molecules of folding helper polypeptides, including one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to the fusion polypeptide. The invention further concerns an immunoassay and the use of the fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising the fusion polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.