Aqueous solution containing bis(N epsilon lauroyllysine)dicarboxylic acid diamide and/or salt thereof, and method for producing same
US10202333B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 6, 2017 |
| Grant date | Feb 12, 2019 |
| Priority date | — |
| Expiry date | Jul 23, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/47
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of producing an aqueous solution containing bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting Nε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding Nε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.