Glucosylceramide synthase inhibitors and therapeutic methods using the same

US10202340B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Scott D. Larsen · Kalamazoo, US
• Akira Abe · Matsumoto, JP
• Liming Shu · Gaithersburg, US
• Michael William Wilson · Foster City, US
• Richard F. Keep · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• James A. Shayman · Ann Arbor, US

Key dates

• Filing date: Feb 1, 2016
• Grant date: Feb 12, 2019
• Expiry date: Feb 1, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.