JAK2 and ALK2 inhibitors and methods for their use

US10202356B2 · kind B2 · utility

Assignee

• TOLERO PHARMACEUTICALS, INC. · US

Inventors

• Alexis Henri Abel Mollard · Salt Lake City, US
• Steven L. Warner · Sandy, US
• Gary A. Flynn · Cincinnati, US
• Hariprasad Vankayalapati · Draper, US
• David J. Bearss · Alpine, US

Key dates

• Filing date: Mar 13, 2014
• Grant date: Feb 12, 2019
• Expiry date: Mar 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.