N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors
US10202375B2 · kind B2 · utility
5Cited by
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24Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 8, 2015 |
| Grant date | Feb 12, 2019 |
| Priority date | — |
| Expiry date | Oct 8, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition, the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example, in treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.