Method of providing disease-specific binding molecules and targets

US10202445B2 · kind B2 · utility

Assignee

• Universitat Zurich · CH

Inventors

• Roger Nitsch · Zumikon, CH
• Christoph Hock · Küsnacht (ZH), CH
• Christoph Esslinger · Bellinzona, CH
• Marlen Knobloch · Tolochenaz, CH
• Kathrin Tissot · Schwanau, DE
• Jan Grimm · Stintenberger Straße, CH

Key dates

• Filing date: May 12, 2017
• Grant date: Feb 12, 2019
• Expiry date: May 12, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.