Patent · US Active

Bi-specific antigen-binding polypeptides

US10202462B2 · kind B2 · utility

1Cited by

1References

9Claims

0Family size

Assignee

X-BODY, INC. · US

Inventors

Yan Chen · Santa Clara, US
Richard W. Wagner · Waterbury, US
Keming Zhang · Waltham, US
Pascale Richalet · Waltham, US

Key dates

Filing date	Mar 20, 2015
Grant date	Feb 12, 2019
Priority date	—
Expiry date	Apr 13, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.