Patent · US Active

Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices

US10202585B2 · kind B2 · utility

1Cited by

144References

35Claims

0Family size

Assignee

LIFEBOND LTD · IL

Inventors

Guy Tomer · Portland, US
Orahn Preiss-Bloom · Caesarea, IL

Key dates

Filing date	Apr 25, 2015
Grant date	Feb 12, 2019
Priority date	—
Expiry date	Jul 3, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y203/02013
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.