Patent · US Active

Vulcanisaetal phosphotriesterase-like lactonases (PLL) having enhanced properties and the uses thereof

US10202587B2 · kind B2 · utility

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1References

15Claims

0Family size

Assignees

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
UNIVERSITÉ D'AIX-MARSEILLE · FR

Inventors

Eric Chabriere · Nancy, FR
Mikael Elias · Florange, FR
Julien Hiblot · Heidelberg, DE
Didier Raoult · Marseilles, FR

Key dates

Filing date	Jul 31, 2014
Grant date	Feb 12, 2019
Priority date	—
Expiry date	Feb 15, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/08001
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided is a mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID NO: 1, the mutated PTE including the at least one mutation chosen amongst 55 putative positions and the mutated PTE having enhanced properties. Also provided are compositions including the mutated hyperthermophilic PTE and the uses thereof, notably as bioscavenger of organophosphate compounds or as quorum quencher of the bacteria using lactones to communicate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.