Adeno-associated virus virions with variant capsid and methods of use thereof

US10202657B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• David V. Schaffer · Danville, US
• Ryan R. Klimczak · San Francisco, US
• James T. Koerber · San Francisco, US
• John G. Flannery · Berkeley, US
• Deniz Dalkara Mourot · Berkeley, US
• Meike Visel · Corona, US
• Leah C. Byrne · Berkeley, US

Key dates

• Filing date: Aug 23, 2016
• Grant date: Feb 12, 2019
• Expiry date: Nov 24, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via intravitreal injection, compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.