Methods for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
US10202658B2 · kind B2 · utility
35Cited by
38References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 2012 |
| Grant date | Feb 12, 2019 |
| Priority date | — |
| Expiry date | May 9, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in combination with one or more mutations at certain other codons. Combinations of mutations associated with hypersusceptibility to NNRTIs are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.