Microfluidic devices for liquid chromatography-mass spectrometry and microscopic imaging

US10203307B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Daojing Wang · Moraga, US
• Pan Mao · Fremont, US
• Rafael Gomez-Sjoberg · Menlo Park, US
• Hung-Ta Wang · Tuscaloosa, US
• Peidong Yang · Somerville, US

Key dates

• Filing date: Jun 3, 2015
• Grant date: Feb 12, 2019
• Expiry date: Feb 20, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/8813
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems, methods, and apparatus provide integration of microscopic imaging and liquid chromatography-mass spectrometry on a microfluidic device. In one aspect, an apparatus includes a first wafer, a second wafer, and an emitter. The emitter is disposed between the first wafer and the second wafer. The first wafer defines a sample input hole. The first wafer and the second wafer define a first channel, the first channel including a first end and a second end. The first end of the first channel is proximate the sample input hole. The first channel is configured to contain separation media. The second end of the first channel is proximate the emitter.