Venule endothelial cell genes and uses thereof

US10206941B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Ulrich H. von Andrian · Sharon, US
• Aude Thiriot · Brookline, US
• Omid C. Farokhzad · Sharon, US
• Jinjun Shi · San Jose, US

Key dates

• Filing date: Jul 9, 2014
• Grant date: Feb 19, 2019
• Expiry date: Jul 9, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are genes which are differentially expressed in venule endothelial cells (V-ECs) compared to non-venule endothelial cells (NV-ECs) and methods and compositions relating to those genes. Also disclosed herein are methods of modulating the venuleness of an endothelial cell or microvessel, methods of modulating leukocyte trafficking, methods of modulating inflammation, methods of targeting agents to tissues based on their ability to bind to surface markers expressed in a microvessel (e.g., venules and non-venules), methods of identifying the venuleness of endothelial cells or microvessels, methods of identifying agents that modulate the venuleness of endothelial cells or microvessels, methods of identifying agents that target microvessels, methods for treating diseases associated with leukocyte trafficking, methods for treating inflammatory diseases, and compositions and kits for use in the methods.