Liquid pentablock co-polymer formulations for sustained delivery of therapeutics
US10207003B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2017 |
| Grant date | Feb 19, 2019 |
| Priority date | — |
| Expiry date | Apr 29, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are amphiphilic polymers compositions for making aqueous formulations. In one aspect, a solution composition for delivery and release of active ingredients comprises a block co-polymer having formula: PEG-PCL-PLA-PCL-PEG or PGA-PCL-PEG-PCL-PGA or PLA-PCL-PEG-PCL-PLA or PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL. The block co-polymers are biodegradable, stable and compatible with hydrophilic, hydrophobic, and combinations thereof, biologic or chemical active agents. In some embodiments, the block co-polymers enable sustained and/or continuous release of various active agents. In certain embodiments, the block co-polymers can be used to make an artificial tear preparation, a lubricant for joints or wound cover or adhesive.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.