Method for cellular RNA expression

US10207009B2 · kind B2 · utility

Assignees

• TRON-Translationale Onkologie an der Universitatsm · DE
• BIONTECH RNA PHARMACEUTICALS GMBH · DE

Inventors

• Ugur Sahin · Mainz, DE
• Tim Beissert · Groß-Gerau, DE
• Marco Poleganov · Frankfurt, DE
• Stephanie Herz · Kasel, DE
• Lars Koste · Mainz, DE

Key dates

• Filing date: May 7, 2015
• Grant date: Feb 19, 2019
• Expiry date: May 28, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.