Patent · US Active

Compositions and methods for delivery of agents

US10207010B2 · kind B2 · utility

86Cited by

36References

24Claims

0Family size

Assignee

ModernaTX, Inc. · US

Inventors

Gilles Besin · Brookline, US
Stephen Hoge · Brookline, US
Joseph Senn · Cambridge, US
Kerry Benenato · Sudbury, US
Staci Sabnis · Somerville, US

Key dates

Filing date	Aug 11, 2017
Grant date	Feb 19, 2019
Priority date	—
Expiry date	Aug 11, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.