Patent · US Active

Isoindoline compositions and methods for treating neurodegenerative disease

US10207991B2 · kind B2 · utility

4Cited by

14References

22Claims

0Family size

Assignee

COGNITO THERAPEUTICS, INC. · US

Inventors

Gilbert M. Rishton · Los Angeles, US
Susan Catalano · Pittsburgh, US
Gary C. Look · Sunnyvale, US

Key dates

Filing date	Sep 11, 2017
Grant date	Feb 19, 2019
Priority date	—
Expiry date	Sep 11, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D491/056
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.