Modified kappa light chain-binding polypeptides

US10208092B2 · kind B2 · utility

Assignee

• GE Healthcare BioProcess R&D AB · SE

Inventors

• Gustav Rodrigo · Uppsala, SE
• Mats Ander · Uppsala, SE
• Tomas Bjorkman · Uppsala, SE

Key dates

• Filing date: Dec 11, 2015
• Grant date: Feb 19, 2019
• Expiry date: Dec 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention discloses kappa light chain-binding polypeptide comprising a mutated binding domain of Peptostreptococcus protein L, wherein at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, SEQ ID NO: 2-6 or 2 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.