Compositions and methods related to recombinant antibodies to histone posttranslational modifications
US10208110B2 · kind B2 · utility
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Key dates
| Filing date | Jun 27, 2014 |
| Grant date | Feb 19, 2019 |
| Priority date | — |
| Expiry date | Feb 18, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark.
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