Lipoprotein nanoplatelets: fluorescent, zwitterionic probes for molecular and cellular imaging
US10209258B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Aug 23, 2016 |
| Grant date | Feb 19, 2019 |
| Priority date | — |
| Expiry date | Jan 6, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5032
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions are provided comprising water-stable semi-conductor nanoplatelets encapsulated in a hydrophilic coating further comprising lipids and lipoproteins. Uses include biomolecular imaging and sensing, and methods of making comprise: colloidal synthesis of CdSe core NPLs; layer-by-layer growth of a CdS shell; and encapsulation of CdSe/CdScore/shell NPLs in lipid and lipoprotein components through an evaporation-encapsulation using zwitterionic phospholipids, detergents, and amphipathic membrane scaffold proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.