Method for enhancing engraftment of haematopoetic stem cells
US10213464B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jan 13, 2012 |
| Grant date | Feb 26, 2019 |
| Priority date | — |
| Expiry date | Nov 21, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel method for enhancing engraftment of haematopoetic stem cells by an ex-vivo pretreatment comprising the steps of obtaining a sample containing haematopoetic stem cells and admixing a prostacyclin analog to obtain a mixture, incubating said mixture for a period of time sufficient to stimulate G alphas-signalling in said cells and optionally and isolating said stimulated cells. Further, a composition comprising a prostacyclin analog for use in the treatment of individuals undergoing haematopoetic stem cell transplantation is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.