Substituted azaspiro(4.5)decane derivatives

US10214520B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Anita WEGERT · Aldenhoven, DE
• Sven Kuehnert · Lehrte, DE
• Rene Michael KOENIGS · Erkelenz, DE
• Bert Nolte · Aachen, DE
• Klaus Linz · Rheinbach, DE
• Stephanie Harlfinger · Basel, CH
• Babette-Yvonne Koegel · Eschweiler, DE
• Paul Ratcliffe · Lanark, GB
• Fritz Theil · Berlin, DE
• Olga Groeger · Berlin, DE
• Birgit Braun · Berlin, DE

Key dates

• Filing date: Jul 14, 2015
• Grant date: Feb 26, 2019
• Expiry date: Jul 14, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.