Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders

US10214545B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Volker Schulze · Hohen Neuendorf, DE
• Knut Eis · Berlin, DE
• Florian Puehler · Wellesley, US
• Ludwig Zorn · Berlin, DE
• Detlev Sülzle · Berlin, DE
• Philip Lienau · Berlin, DE
• Antje Margret Wengner · Berlin, DE
• Kirstin Petersen · Berlin, DE
• Ulf Bömer · Glienicke, DE

Key dates

• Filing date: Jan 6, 2015
• Grant date: Feb 26, 2019
• Expiry date: Sep 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, E, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.