Patent · US Active

Variants of IgG-Fc fusion that provide for site-specific conjugation at the N-terminus

US10214578B1 · kind B1 · utility

0Cited by
0References
16Claims
0Family size

Inventor

Key dates

Filing dateJul 20, 2016
Grant dateFeb 26, 2019
Priority date—
Expiry dateJul 20, 2036

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/33
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Conjugated lysine-depleted variants of fragment crystallizable (Fc) regions of immunoglobulins are disclosed. Also disclosed are fusion proteins comprised of C-terminal targeting peptide sequences, fused to such lysine-depleted variant IgG-Fc domains. Polynucleotides encoding such proteins, compositions and kits containing such proteins, and methods of using such proteins are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.