Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells
US10214724B2 · kind B2 · utility
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Key dates
| Filing date | Apr 4, 2017 |
| Grant date | Feb 26, 2019 |
| Priority date | — |
| Expiry date | Apr 4, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/45
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB) formation.
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