Heparinases obtained from Sphingobacterium daejeonense, preparation therefor and application thereof
US10214735B2 · kind B2 · utility
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Key dates
| Filing date | May 25, 2015 |
| Grant date | Feb 26, 2019 |
| Priority date | — |
| Expiry date | May 25, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Isolated and prepared heparinases SDhep I and SDhep II obtained from a bacterium Sphingobacterium daejeonense are heparin enzymes that have not been reported. The isolated and prepared enzymes were obtained by steps of bacterium fermentation, crude enzyme extraction, multi-step column chromatography and so on. A study in properties showed that the two enzymes are specific for enzymolysis of heparin and are expected to be used in low molecular weight heparins preparation or heparin quality testing.
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