Tetragalnac containing conjugates and methods for delivery of oligonucleotides
US10214742B2 · kind B2 · utility
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Key dates
| Filing date | Nov 29, 2016 |
| Grant date | Feb 26, 2019 |
| Priority date | — |
| Expiry date | Apr 20, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/351
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.