Real-time imaging sensor for measuring cellular thiol level
US10215757B2 · kind B2 · utility
2Cited by
0References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 18, 2015 |
| Grant date | Feb 26, 2019 |
| Priority date | — |
| Expiry date | Nov 18, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.