Treatment and prevention of stroke and other neurological disorders
US10220008B2 · kind B2 · utility
0Cited by
15References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 14, 2014 |
| Grant date | Mar 5, 2019 |
| Priority date | — |
| Expiry date | Nov 21, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5058
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.