(Thio, oxo, and seleno) semicarbazone complexes with zinc and their use for treating cancer

US10221133B2 · kind B2 · utility

Assignees

• Rutgers, the State University of New Jersey · US
• The Research Foundation for The State University of New York · US

Inventors

• David J. Augeri · Princeton, US
• Anthony F. Bencivenga · New Brunswick, US
• Adam Blanden · Manlius, US
• Darren R. Carpizo · New Brunswick, US
• John A. Gilleran · New Brunswick, US
• Spencer David Kimball · Plainsboro, US
• Stewart N. Loh · Manlius, US
• Xin Yu · South San Francisco, US

Key dates

• Filing date: Jan 27, 2016
• Grant date: Mar 5, 2019
• Expiry date: Jan 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides organic complexes of Zn2+ of formula (I) that are useful for treating cancer, as well as compositions and kits comprising such complexes, and intermediate monomer compounds that are useful for the preparation of such complexes.