Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents
US10221158B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Sep 8, 2016 |
| Grant date | Mar 5, 2019 |
| Priority date | — |
| Expiry date | Sep 8, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus:The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a therapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.
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