Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1

US10221175B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• P. Jeffrey Conn · Brentwood, US
• Craig W. Lindsley · Brentwood, US
• Kyle A. Emmitte · Durham, US
• Changho Han · Nashville, US
• Julie L. Engers · Brentwood, US
• Aaron M. Bender · Spring Hill, US

Key dates

• Filing date: Apr 22, 2016
• Grant date: Mar 5, 2019
• Expiry date: Apr 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted pyrrolopyridine, imidazopyridine and triazolopyridine compounds having a formula are positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1) and the compounds and their pharmaceutical compositions may be useful in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Compounds of the invention may be prepared in several steps from 2-halo-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one intermediates.