Patent · US Active

Preparation of certain substituted [((6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines and pharmaceutically acceptable salts thereof

US10221176B2 · kind B2 · utility

23Cited by

54References

29Claims

0Family size

Assignee

INTRA-CELLULAR THERAPIES, INC. · US

Inventors

John Charles Tomesch · Succasunna, US
Peng Li · New York, US
Wei Yao · Shanghai, CN
Qiang Zhang · Dalian, CN
James David Beard · New York, US
Andrew S. Thompson · Mountainside, US
Hua Cheng · Plainsboro, US
Lawrence P. Wennogle · Fryeburg, US

Key dates

Filing date	Jul 26, 2017
Grant date	Mar 5, 2019
Priority date	—
Expiry date	Jul 26, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines of Formula 2F, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, such methods comprising the preparation of a Compound of Formula 2F, as shown below and as further defined herein:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.