Patent · US Active

Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides

US10221205B2 · kind B2 · utility

2Cited by

2References

20Claims

0Family size

Assignee

Sirna Therapeutics, Inc. · US

Inventors

David M. Tellers · Lansdale, US
Steven L. Colletti · Princeton Junction, US
Vadim Dudkin · Lansdale, US
Jeffrey Aaronson · Johnstown, US
Aaron Momose · Johnstown, US
Thomas J. Tucker · North Wales, US
Yu Yuan · Sichuan, CN
Kathleen B. Calati · Hillsborough Township, US
Lu Tian · Jamison, US
Rubina G. Parmar · Cambridge, US
Anthony W. Shaw · Johnstown, US
Weimin Wang · Hangzhou City, CN
Rachel Anne Storr · Johnstown, US
Marina Busuek · Johnstown, US
Robert A. Kowtoniuk · Johnstown, US

Key dates

Filing date	Nov 8, 2017
Grant date	Mar 5, 2019
Priority date	—
Expiry date	Nov 8, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3513
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.