Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof
US10221408B2 · kind B2 · utility
2Cited by
31References
18Claims
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Key dates
| Filing date | Apr 15, 2016 |
| Grant date | Mar 5, 2019 |
| Priority date | — |
| Expiry date | Apr 15, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. Further provided are compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, formulation, and use of such compositions for industrial and therapeutic purposes, e.g., treating hyperphenylalaninemia, including phenylketonuria, and other disorders, including cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.